Negative regulation of Toll-like receptor-mediated immune responses
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- 1 June 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 5 (6) , 446-458
- https://doi.org/10.1038/nri1630
Abstract
Toll-like receptors (TLRs) are involved in host defence against invading pathogens, functioning as primary sensors of microbial products and activating signalling pathways that induce the expression of immune and pro-inflammatory genes. However, TLRs have also been implicated in several immune-mediated and inflammatory diseases. As the immune system needs to constantly strike a balance between activation and inhibition to avoid detrimental and inappropriate inflammatory responses, TLR signalling must be tightly regulated. Here, we discuss the various negative regulatory mechanisms that have evolved to attenuate TLR signalling to maintain this immunological balance.Keywords
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