Metabolism in Rats of Several Carboxylic Acid Derivatives Containing the 3,4‐Methylenedioxyphenyl Group

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Abstract
The metabolism of the 3,4-methylenedioxy derivatives of mandelic acid, phenylacetic acid, benzoic acid, 3-phenylpropionic acid and cinnamic acid was studied in rats. Following intragastric dosage (1 mmol/kg) the compounds and their metabolites were excreted in the urine within 24 h. Recoveries of .apprx. 85% were obtained. Except for mandelic acid which was excreted to a large extent unchanged, Gly conjugates were the major urinary metabolites. Phenylacetic acid formed 3,4-methylenedioxyphenylacetylglycine; the other 3 compounds were converted to 3,4-methylenedioxybenzoylglycine. No evidence was found with any compound for demethylenation and excretion of catecholic metabolites.