Imaging Pancreatic Cancer Using Surface-Functionalized Quantum Dots
- 1 June 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Physical Chemistry B
- Vol. 111 (25) , 6969-6972
- https://doi.org/10.1021/jp070620n
Abstract
In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.Keywords
This publication has 9 references indexed in Scilit:
- Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism ArraysCancer Research, 2006
- Synthesis of High Quality Zinc Blende CdSe NanocrystalsThe Journal of Physical Chemistry B, 2005
- CdSe/CdS/ZnS and CdSe/ZnSe/ZnS Core−Shell−Shell NanocrystalsThe Journal of Physical Chemistry B, 2004
- NanophotonicsPublished by Wiley ,2004
- Claudin 4 Protein Expression in Primary and Metastatic Pancreatic CancerAmerican Journal of Clinical Pathology, 2004
- Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseCancer Cell, 2003
- Highly Emissive Colloidal CdSe/CdS Heterostructures of Mixed DimensionalityNano Letters, 2003
- Epitaxial Growth and Photochemical Annealing of Graded CdS/ZnS Shells on Colloidal CdSe NanorodsJournal of the American Chemical Society, 2002
- Semiconductor Nanocrystals as Fluorescent Biological LabelsScience, 1998