ENDOMETRIAL AND SERUM GENTAMICIN CONCENTRATIONS IN PONY MARES GIVEN REPEATED INTRAUTERINE INFUSIONS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 46  (5) , 1025-1028
Abstract
Endometrial tissue and blood serum gentamicin (GT) [given for treatment of bacterial metritis] concentrations were determined in 6 ovariectomized pony mares given intrauterine infusions (50 ml of a 5% commercial aqueous solution of (GT) each day for 5 consecutive days. The mares were subjected to the following 3 treatments: GT infusion only (trial A, control); progesterone plus GT (trial B,P + G); and estradiol plus GT (trial C,E + G). Endometrial tissue concentrations of GT (.mu.g/g) at 24 and 120 h were significantly higher (P < 0.05) in trials B (65.54 .+-. 15.57 and 100.33 .+-. 19.27) and C (73.33 .+-. 22.53 and 74.09 .+-. 8.60) than in trial A (4.23 .+-. 0.70). Endometrial concentration for trial A at 24 h. There was no significant difference (P > 0.05) in endometrial concentrations among trials A, B, and C at 120 h. Serum GT concentrations were significantly lower than endometrial tissue concentrations. The highest serum concentrations of GT found in every trial occurred at 6 h after each intrauterine infusion of GT. The highest overall serum concentration of GT (.mu.g/ml) determined occurred in trial B (8.30 .+-. 1.28) at 78 h. There was no significant difference in serum concentrations of GT between days of treatment, except for trial A at 78 and 102 h, respectively. Serum concentrations of GT were significantly higher (P < 0.05) than trial A at 30, 54, 78, and 102 h in trial B, and at 78 and 102 h in trial C. There was no significant difference in serum concentrations of GT between trials B and C.