Potent antitumor antibiotic complex: PD 114,759, PD 115,028, PD 119,707, and PD 119,193.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (10) , 1337-1343
- https://doi.org/10.7164/antibiotics.38.1337
Abstract
Four novel antitumor antibiotics (PD-114,759, PD-115,028, PD-119,707, and PD-119,193) are produced as a complex by a new species of Actinomadura. The proposed name for the culture is Actinomadura verrucosospora subsp. veractimyces ATCC 39363. The antibiotics are extremely bioactive, with MIC values of < 0.006 ng/ml against several bacteria and ID50 values of 0.003 .apprx. 0.17 ng/ml against L1210 leukemia cells in vitro. Antitumor activities vs. P388 leukemia in vivo were observed at doses of 0.313, 0.40, and 0.5 .mu.g/kg (daily .times. 5) for PD 119,707, PD 115,028, and PD 114,759, respectively.This publication has 1 reference indexed in Scilit:
- PD 114,759 and PD 115,028, novel antitumor antibiotics with phenomenal potency. I. Isolation and characterization.The Journal of Antibiotics, 1984