Pathophysiological Manifestations in Mice Exposed to Anthrax Lethal Toxin
Open Access
- 1 October 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (10) , 7006-7010
- https://doi.org/10.1128/iai.73.10.7006-7010.2005
Abstract
Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.Keywords
This publication has 15 references indexed in Scilit:
- Anthrax Lethal Toxin Induces Endothelial Barrier DysfunctionThe American Journal of Pathology, 2005
- ATR/TEM8 is highly expressed in epithelial cells liningBacillus anthracis’three sites of entry: implications for the pathogenesis of anthrax infectionAmerican Journal of Physiology-Cell Physiology, 2005
- Mouse Susceptibility to Anthrax Lethal Toxin Is Influenced by Genetic Factors in Addition to Those Controlling Macrophage SensitivityInfection and Immunity, 2004
- Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in ratsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2004
- Anthrax Lethal Toxin Induces Human Endothelial Cell ApoptosisInfection and Immunity, 2004
- Hemeoxygenase-1 in SJL mice with experimental allergic encephalomyelitisMultiple Sclerosis Journal, 2003
- Fatal Inhalational Anthrax in a 94-Year-Old Connecticut WomanJAMA, 2002
- Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor ProteinInfection and Immunity, 2001
- Quantitative Pathology of Inhalational Anthrax I: Quantitative Microscopic FindingsLaboratory Investigation, 2001
- Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979.Proceedings of the National Academy of Sciences, 1993