Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral
- 1 February 2008
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 9,p. 1100-1102
- https://doi.org/10.1039/b719603b
Abstract
A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method.Keywords
This publication has 22 references indexed in Scilit:
- Advanced Organic Synthesis Using Microreactor TechnologyChemInform, 2007
- Optimization of Glycosylation Reactions in a MicroreactorHelvetica Chimica Acta, 2007
- Accelerating Reactions with Microreactors at Elevated Temperatures and Pressures: Profiling Aminocarbonylation ReactionsAngewandte Chemie International Edition in English, 2007
- Microreactors as Tools for Synthetic Chemists—The Chemists' Round‐Bottomed Flask of the 21st Century?Chemistry – A European Journal, 2006
- Microreactor Synthesis of β‐PeptidesAngewandte Chemie International Edition in English, 2006
- A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocolsChemical Communications, 2006
- A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assemblyChemical Communications, 2006
- Critical Assessment of Pharmaceutical ProcessesA Rationale for Changing the Synthetic RouteChemical Reviews, 2006
- Chemistry in Microstructured ReactorsAngewandte Chemie International Edition in English, 2004
- Chemical Synthesis in MicroreactorsChimia, 2002