Effect of Bile Infusion on the Dog Kidney

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Abstract
TRADITIONALLY, the surgeon approaches the jaundiced patient with extreme care. His attitude arises from the high postoperative morbidity and mortality in jaundiced patients undergoing operations that otherwise carry little risk.1 In more than 50 per cent of such patients who die after surgery death has been due to renal failure and uremia. Almost invariably hypotension has occurred during the clinical course. Pathological studies of kidneys from patients dying of renal failure while jaundiced have shown a vacuolization of the tubular cells, suggestive of direct renal damage. Moreover, hyperbilirubinemia has appeared to make the kidney more susceptible to ischemic damage.2 Infusion . . .