Acute Pancreatic Lesions in Patients Treated with ACTH and Adrenal Corticoids

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Abstract
CASUAL observations of post-mortem material have suggested an increased frequency of necrosis and other lesions in the pancreas and adjacent tissues in patients receiving certain adrenocortical steroids or ACTH. The present study is an attempt at a more accurate quantitative evaluation of these findings.Our interest was stimulated by reports from two laboratories of pancreatic lesions induced by cortisone in rabbits. Stumpf and his co-workers1 found changes in pancreatic acini in 44 of 53 cortisone-treated animals and peripancreatic fat necrosis in 13 of these animals. Bencosme and Lazarus2 described similar lesions in their series of rabbits treated with this steroid. . . .