Clofibrate-Induced Myotoxicity in Rats
- 31 December 1983
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 23 (3) , 182-197
- https://doi.org/10.1159/000115701
Abstract
The temporal sequence of myopathology during a clofibrate-induced muscular syndrome and its recovery in rats is described using histopathologic, histochemical and electron microscopic techniques. Two stages of myopathology are described: an early stage characterized by myopathic features, and a later stage characterized by neurogenic features. Although muscle histology returns to normal after 1 wk of discontinuing the drug, electron microscopic abnormalities persist through the 2nd wk. It is proposed that clofibrate, in addition to its myotoxic effect, may be neurotoxic.Keywords
This publication has 1 reference indexed in Scilit:
- Clofibrate-induced myopathy in patients with diabetes insipidus.Endocrinologia Japonica, 1980