Chemical Changes in Rabbit Brain During Anoxia

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Abstract
Changes in metabolite concns. of various portions of the rabbit brain were detd. during progressive stages of anoxia and correlated with electrical measurements of function. Disappearance of function and inexcitability of all measurable elements during anoxia were associated with a moderate decrease of ATP, phosphocreatine and glycogen. Disappearance of ATP was more rapid than that of phosphorcreatine. Loss of spontaneous electrical activity during early stages of anoxia occurred before significant changes in chemical constituents could be detected, when the exptl. animals were compared to unanesthetized controls. Urethane controls, on the other hand, had a higher level of ATP than the unanesthetized animals. There was a significant decrease during all stages of anoxia. The different regions of the forebrain showed no differences in ATP level nor in depletion under anoxia. This level, however, was lower in the mesencephalon and the medulla, and depletion occurred more slowly.

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