Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro.
Open Access
- 1 December 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (12) , 5718-5721
- https://doi.org/10.1128/mcb.9.12.5718
Abstract
Ets1 and Ets2 are nuclear phosphoproteins which bind to DNA in vitro and share two domains of strong identity. Deletion analyses of each of these conserved regions in Ets1 demonstrated that integrity of the carboxy-terminal domain, also conserved in the more distantly related elk and erg gene products, is essential for both nuclear targeting and DNA-binding activity in vitro.This publication has 24 references indexed in Scilit:
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