FUNCTION AND METABOLISM OF CATECHOLAMINES IN THE BRAIN
Open Access
- 1 January 1964
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 14 (2) , 181-193
- https://doi.org/10.1254/jjp.14.181
Abstract
Catecholoxymethyl trans-ferase (COMT) as well as monoamineoxidase (MAO) plays a significant role in the inactivation of endogenous and exogenous norepinephrine in rabbit brain. Win 18501-2 depletes selectively the content of norepinephrine in rabbit brain. Sedation induced by resperine on Win 18501-2 seems to be related to the depletion of brain norepinephrine. In addition to MAO blockade iproniazid and Catron seem to produce a strong binding of norepinephrine with receptors in the brain.Keywords
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