Direct observation of B-form and Z-form DNA by scanning tunneling microscopy
- 1 March 1991
- journal article
- research article
- Published by American Vacuum Society in Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures
- Vol. 9 (2) , 1298-1303
- https://doi.org/10.1116/1.585225
Abstract
Using a scanning tunneling microscope (STM) of atomic resolution, we have directly observed variant conformations of DNA, including normal B-form and Z-form DNA, with a modified working condition. STM images of natural fish sperm and calf thymus B-form DNA and poly (dG-me5 dC) and bromized poly dCG Z-form DNA have been obtained at a subnatural environment. These results have provided some new evidence that images characteristic of DNA molecules can be obtained with STM.This publication has 4 references indexed in Scilit:
- Images of the DNA Double Helix in WaterScience, 1989
- Scanning Tunneling Microscopy of Nucleic AcidsScience, 1989
- Direct Observation of Native DNA Structures with the Scanning Tunneling MicroscopeScience, 1989
- Parallel stranded duplex DNANucleic Acids Research, 1988