In vivo metabolism of dimethylformamide and relationship to toxicity in the male rat
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 56 (2) , 87-91
- https://doi.org/10.1007/bf00349077
Abstract
After in vivo administration of dimethylformamide (DMF) to male rats, about 50% of the dose is excreted in urine as N-hydroxymethyl-N-methylformamide (DMF-OH) and about 4% as N-methylformamide (NMF). NMF is not a product of DMF-OH biotransformation but is directly formed from DMF. Comparison of the acute toxicity of DMF, DMF-OH and NMF shows that NMF is more toxic than DMF-OH, which is itself more toxic than DMF. This study explains the different toxicity profile of DMF and NMF which until recently was believed to represent the main metabolite of DMF.Keywords
This publication has 16 references indexed in Scilit:
- In vivo and in vitro oxidative biotransformation of dimethylformamide in ratChemico-Biological Interactions, 1984
- An investigation of the mechanism of hepatotoxicity of the antitumour agent N-methylformamide in miceBiochemical Pharmacology, 1984
- Study on in vivo and in vitro metabolism of dimethylformamide in male and female ratsToxicology, 1984
- Relation of exposure to dimethylformamide vapor and the metabolite, methylformamide, in urine of workersInternationales Archiv für Arbeitsmedizin, 1980
- Detection and identification of S-methylcysteine in urine of workers exposed to methyl chlorideInternationales Archiv für Arbeitsmedizin, 1980
- Monomethylformamide Levels in Human Urine After Repetitive Exposure to Dimethylformamide VaporJournal of Occupational and Environmental Medicine, 1978
- Metabolism studies of N,N-dimethylformamideInternationales Archiv für Arbeitsmedizin, 1975
- Metabolism studies of N,N-dimethylformamideInternationales Archiv für Arbeitsmedizin, 1975
- The Determination of N-Methylformamide and N-Methylacetamide in UrineAihaj Journal, 1974
- Tissue sulfhydryl groupsArchives of Biochemistry and Biophysics, 1959