Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes
- 7 October 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 190 (1) , 161-164
- https://doi.org/10.1016/0014-5793(85)80449-x
Abstract
Acetylcholine treatment of [3H]inositol pre-labelled cultured chick embryo myotubes results in the stimulation of phosphatidylinositol breakdown, as shown by the measurement of inositol-1-phosphate accumulating in the presence of lithium. The described effect is dependent on agonist concentration and incubation time, and is inhibited by tubocurarine and α-bungarotoxin. The activation of phosphatidylinositol breakdown by acetylcholine at extrajunctional nicotinic receptors is likely to be involved in the modulation of the functional activity of the receptor.Keywords
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