Kidney Function in Acromegaly

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Abstract
Creatinine clearance and daily urinary albumin and .beta.2-microglobulin excretion rates (radioimmunoassays [RIA]) were measured several times in 14 patients with acromegaly. Eleven patients were treated with bromocriptine, 5 to 55 mg/day. The activity of the disease was assessed by measuring urinary growth hormone [GH] excretion (RIA). In agreement with previous investigations the creatinine clearance was elevated. No correlation was found between this variable and the urinary GH excretion. Urinary albumin and .beta.2-microglobulin excretion rates were not significantly different from previous results in 27 adults control subjects. There was no correlation between urinary GH excretion and urinary albumin or .beta.2-microglobulin excretion rates. Bromocriptine treatment reduced urinary GH excretion from 200-91 ng/24 h, P < 0.01, but no significant alterations were induced in the above mentioned kidney function variables.

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