STUDIES ON THE CHANGE IN IONIC PERMEABILITY OF BRAIN SLICES

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Abstract
A remarkable decrease in the K+ content in brain slices was caused by addition of protoveratrine, ouabain or ethylenediamine tetraacetic acid(EDTA.) The effect of these drugs seemed to be reversible, temperature dependent and metabolic independent. Cocaine, procaine and Ca++ prevented any change caused by protoveratrine, ouabain or EDTA. The changes in K+ content caused by these drugs shown with brain slices were not observed with liver slices. From these results it is suggested that the change observed may be closely related to physiological depolarization of excitable membrane.