Enduring Behavioral Changes in Rats with Experimental Phenylketonuria

Open Access

1 April 1972

journal article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 69 (4) , 863-867
https://doi.org/10.1073/pnas.69.4.863

Abstract

Several criticisms of past attempts to produce experimental phenylketonuria are discussed, and a model that appears to meet these criticisms is presented. This model uses inhibition in rats of phenylalanine hydroxylase (EC 1.14.3.1) by p-chlorophenylalanine and supplementation with phenylalanine to produce a high ratio of phenylalanine to tyrosine in their blood. By this method, an experimental subject is produced whose behavioral, neurological, and biochemical characteristics are similar to those of clinical patients with phenylketonuria.

Keywords

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