Changes in the protein composition of muscles of the rat in hypertrophy and atrophy

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Abstract
The gain in weight of the hemidiaphragm of the rat caused to hypertrophy by denervation was associated with an increase in protein. The increase in protein in the hypertrophy caused by hormones was confirmed for the levator ani muscle of the rat. The percentage composition of the muscle was unchanged during the periods of hypertrophy and return to normal weight. With further loss of weight, the percentage of contractile proteins decreased and a corresponding increase in percentage of connective tissue occurred. At 7 days after denervation a 36% in absolute amount of sarcoplasmic protein accompanied by a 27% increase in absolute amount of contractile protein was observed. At 45 days decreases in absolute amount of these 2 fractions of 45 and 54% respectively had occurred. There was no significant change in absolute amount of connective tissue during the period studied.