Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 Modifications
- 1 December 1998
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 8 (23) , 3409-3414
- https://doi.org/10.1016/s0960-894x(98)00613-1
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- New thrombin inhibitors in cardiovascular diseaseCurrent Opinion in Chemical Biology, 1997
- Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitorBioorganic & Medicinal Chemistry Letters, 1997
- New routes to conformationally restricted peptide building blocks: a convenient preparation of bicyclic piperazinone derivativesBioorganic & Medicinal Chemistry Letters, 1996
- Potent and Selective Thrombin Inhibitors Incorporating the Constrained Arginine Mimic l-3-Piperidyl(N-guanidino)alanine at P1Journal of Medicinal Chemistry, 1996
- Structure-Actmty Relationships of Inhibitors Derived from 3-AmidinophenylalanineJournal of Enzyme Inhibition, 1995
- Direct thrombin inhibitors in cardiovascular medicine.Circulation, 1994
- Hirudin and Hirulog: Advances in antithrombotic therapyPerspectives in Drug Discovery and Design, 1994
- Small-molecule inhibitors of thrombinPerspectives in Drug Discovery and Design, 1994
- Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profileTrends in Pharmacological Sciences, 1993