Hepatitis and Bone Destruction as Uncommon Manifestations of Early Syphilis

Abstract
We describe a patient with a painful lytic lesion of the clavicle and a granuloma of the liver in late secondary syphilis. The classic "moth-eaten" alopecia of the scalp as well as eyebrows and eyelashes suggested syphilis, although an initial false-negative VDRL test for syphilis (prozone phenomenon) caused a delay in diagnosis. Bone as well as liver involvement in early syphilis may be more common than previously recognized. (Arch Dermatol 112:1451-1454, 1976)

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