Pathophysiological role of calpain in experimental demyelination
- 23 February 1999
- journal article
- review article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 55 (5) , 533-541
- https://doi.org/10.1002/(sici)1097-4547(19990301)55:5<533::aid-jnr1>3.0.co;2-8
Abstract
Calcium‐activated neutral proteinase (calpain) has been extensively studied over the past three decades such that many enzymatic and structural properties of this enzyme are well understood. However, the pathophysiological roles of calpain remain poorly defined. In addition to recent studies delineating a role for calpain in various pathological conditions, this proteinase has been implicated in the degradation of myelin proteins in autoimmune demyelinating diseases such as multiple sclerosis and experimental allergic encephalomyelitis (EAE). In EAE, calpain translational expression is significantly increased in activated glial/inflammatory cells that participate in myelinolysis while calpain substrates (axonal and myelin proteins) are lost. Thus, since all major myelin proteins are calpain substrates, early studies suggest calpain may play an important role in demyelination of the central nervous system. J. Neurosci. Res. 55:533–541, 1999.Keywords
This publication has 65 references indexed in Scilit:
- Mechanisms of Calpain Proteolysis Following Traumatic Brain Injury: Implications for Pathology and Therapy: A Review and UpdateJournal of Neurotrauma, 1997
- Regulation of brain m calpain Ca2+ sensitivity by mixtures of membrane lipids: Activation at intracellular Ca2+ levelJournal of Neuroscience Research, 1996
- Endogenous Cleavage of Phospholipase C-β3 by Agonist-induced Activation of Calpain in Human PlateletsPublished by Elsevier ,1995
- Calpain-induced down-regulation of protein kinase C inhibits dense-granule secretion in human platelets. Inhibition of platelet aggregation or calpain activity preserves protein kinase C and restores full secretionBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994
- Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.Stroke, 1994
- The calpain—calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cellsFEBS Letters, 1994
- Modulation of Calpastatin Specificity in Rat Tissues by Reversible Phosphorylation and DephosphorylationBiochemical and Biophysical Research Communications, 1994
- Ganglioside‐Modulated Proteolysis by Ca2+‐Activated Neutral Proteinase (CANP): A Role of Glycoconjugates in CANP RegulationJournal of Neurochemistry, 1990
- Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological functionFEBS Letters, 1987
- Tissue culture demyelination by normal human serumAnnals of Neurology, 1984