Dimaprit inhibition of zymosan-stimulated beta-glucuronidase release from human granulocytes
- 1 April 1980
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 10 (1-2) , 15-18
- https://doi.org/10.1007/bf02024173
Abstract
Histamine inhibits the in vitro release of granulocytic lysosomal beta-glucuronidase when incubated with complement activated zymosan particles and this is an H2-receptor response. The highly specific histamine H2-receptor agonist, dimaprit, also inhibits this secretory enzyme release but is less potent (-log molar ED50 6.71 with histamine vs.-log ED50 5.97 with dimaprit,pK B =2.9×10−8 M with histamine andK B =3.6×10−8 M with dimaprit). Diphenhydramine did not change the granulocyte response to either histamine or dimaprit.Keywords
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