Target concentration intervention: beyond Y2K
- 1 July 1999
- journal article
- editorial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 48 (1) , 9-13
- https://doi.org/10.1046/j.1365-2125.1999.00971.x
Abstract
Target concentration intervention (TCI) is proposed as an alternative conceptual strategy to therapeutic drug monitoring (TDM). It is argued that the idea of a therapeutic range has limited the interpretation of measured drug concentrations and diminished the anticipated clinical benefit to patients by use of an oversimplified pharmacodynamic model. TCI on the other hand embraces pharmacokinetic and pharmacodynamic concepts and uses the idea of a target effect and associated target concentration to make rational individual dose decisions.Keywords
This publication has 19 references indexed in Scilit:
- Holford NHG and Sheiner LB “Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models”, Clin Pharmacokin 6:429–453 (1981)—The BackstoryThe AAPS Journal, 2011
- Best practice in therapeutic drug monitoringBritish Journal of Clinical Pharmacology, 1998
- Therapeutic drug monitoring beyond 2000British Journal of Clinical Pharmacology, 1998
- Model-Based, Goal-Oriented, Individualised Drug TherapyClinical Pharmacokinetics, 1998
- Target Concentration Strategy for Cyclosporin MonitoringClinical Pharmacokinetics, 1997
- Theophylline Target Concentration in Severe Airways Obstruction - 10 or 20 mg/L?Clinical Pharmacokinetics, 1993
- Time and Theophylline Concentration Help Explain the Recovery of Peak Flow Following Acute Airways ObstructionClinical Pharmacokinetics, 1993
- The importance of modeling interoccasion variability in population pharmacokinetic analysesJournal of Pharmacokinetics and Biopharmaceutics, 1993
- Comparison of Drug Dosing MethodsClinical Pharmacokinetics, 1985
- Understanding the Dose-Effect RelationshipClinical Pharmacokinetics, 1981