The Role of Phagocytic Cells in the Immune Reaction of Rabbit Blood Lymphocytes in Antigen Stimulated Cultures

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Abstract
A reduction in blastoid transformation, development of plaque‐forming cells and liberation of agglutinins was noticed in blood lymphocyte cultures stimulated with sheep red cells (SRC), when the cultures were prepared with reduced numbers of phagocytic cells. In cultures which gave a high immune response, numerous rosettes composed of a central macrophage surrounded by proliferating lymphocytes, were observed. The findings support the view that phagocytic cells may play an important role in preparation and transfer of antigen to lymphocytes which are able to proliferate and transform into antibody producing cells.