Effect of Age on the Establishment of Muscle Paralysis Induced in Anaesthetized Adult Subjects by ORG NC 45

Publisher Website
Google Scholar
Abstract
The establishment of muscle paralysis produced by a single dose of 70 μg · kg‐1of ORG NC 45 was studied in 30 healthy anaesthetized patients, aged 15–85 years, by recording adductor pollicis isometric mechanical activity‐twitch height (TH). Significant correlations were observed between age and the latency of ORG NC45 action, defined as the reduction of TH to 95% of its initial value (r: 0.315,PP<0.005). Correlation between age and maximum TH depression was not significant. These results show that if the maximum TH depression observed after a standard dose of ORG NC 45 is not altered by the age of the patient, the establishment of the paralysis is delayed by ageing.