Edema of the Spinal Cord in Experimental Allergic Encephalomyelitis.

Abstract
Summary The hyperacute form of experimental allergic encephalomyelitis produced inflammatory edema of the CNS, with 3-18% swelling of the cord but not of the brain; the magnitude of change paralleled the severity of disease. Overhydration (water intoxication) caused 6-7% swelling of the spinal cord, and changes of similar degree occurred in the brain. The combination of overhydration and inflammatory edema had an additive effect on water content of the spinal cord.