AMPHENONE: TOXICITY AND EFFECTS ON ADRENAL AND THYROID FUNCTION IN MAN

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Abstract
Endocrinologic and toxicologic data are presented on patients treated with Amphenone, (1, 2-bis(p-aminophenyl) 2-methyl propanone-1-dihydrochloride) a compound known to inhibit both adrenal and thyroid function in several species. A marked suppression of urinary 17 hydroxycorticoid excretion not accompanied by a similar fall in the urinary 17-ketosteroids was seen in 7 of 10 patients so studied. Serum 17-hydroxycorticoid concentration was irregularly suppressed. Two patients who died of breast carcinoma while receiving Amphenone showed two- to threefold adrenal enlargement comparable to that seen after prolonged ACTH administration. Amphenone also inhibited organic binding of iodide by the thyroid. More consistent suppression could not be obtained because of limitation of dosage by toxic side effects, chiefly central nervous system depression.