Glucose and Cation Transport in Rat Jejunum, Ileum and Colon in vivo: Effects of Anionic and Nonionic Surfactants, and of Desoxycholate

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Abstract
Osmotically balanced solutions of glucose (0.5-300 mM) and NaCl, containing surfactants, were instilled into the small or large intestine of anesthetized rats. Net absorption or secretion of glucose, Na and K was studied. The surfactants tested were dodecylsulfate (3.4-17 mM), dioctylsulfosuccinate (1.8-11 m/M). Lubrol WX (0.1-0.5%), Triton X100 (0.25%) and desoxycholate (2.5 mM). Qualitatively, the results were similar to those obtained previously with cationic compounds, suggesting a common mode of action for all surfactants studied. Dodecylsulfate (17 mM) seemed to abolish completely physiological glucose transport in the jejunum and ileum. At a lower concentration, and with the other surfactants, normal glucose transport was affected to an intermediate extent.

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