EFFECTS OF CHANGING LEVELS OF GLUCOCORTICOSTEROIDS ON HEAT EXPOSURE IN RABBIT

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Abstract
Rabbits exposed for 1 h to a temperature of 40.degree. C and 35-37% humidity showed elevated plasma osmolality and pH. Most of the animals were not able to withstand the heat. Dexamethasone-treated rabbits under the same conditions withstood the heat better and their plasma pH and osmolality remained constant. Metopirone-treated rabbits withstood the heat and showed a rise in plasma osmolality and a slight change in plasma pH. The highest rise in rectal temperature was observed in the metopirone-treated rabbits. Only the untreated animals were unable to regain pre-exposure rectal temperature. High levels of glucocorticosteroids may enhance neurogenic and metabolic mechanisms which have protective functions during acute exposure to heat.