Evolving questions and paradigm shifts in endoplasmic‐reticulum‐associated degradation (ERAD)
- 18 August 2003
- Vol. 25 (9) , 868-877
- https://doi.org/10.1002/bies.10320
Abstract
ER‐associated degradation (ERAD) is a component of the protein quality control system, ensuring that aberrant polypeptides cannot transit through the secretory pathway. This is accomplished by a complex sequence of events in which unwanted proteins are selected in the ER and exported to the cytosol for degradation by the proteasome. Given that protein quality control can be essential for cell survival, it is not surprising that ERAD is linked to numerous disease states. Here we review the molecular mechanisms of ERAD, its role in metabolic regulation and biomedical implications, and the unanswered questions regarding this process. BioEssays 25:868–877, 2003.Keywords
This publication has 106 references indexed in Scilit:
- A single viral protein HCMV US2 affects antigen presentation and intracellular iron homeostasis by degradation of classical HLA class I and HFE moleculesBlood, 2003
- Inhibition of Endoplasmic Reticulum-Associated Degradation in CHO Cells Resistant to Cholera Toxin, Pseudomonas aeruginosa Exotoxin A, and RicinInfection and Immunity, 2002
- Unassembled Ig Heavy Chains Do Not Cycle from BiP In Vivo but Require Light Chains to Trigger Their ReleaseImmunity, 2001
- Membrane Topology and Function of Der3/Hrd1p as a Ubiquitin-Protein Ligase (E3) Involved in Endoplasmic Reticulum DegradationJournal of Biological Chemistry, 2001
- Apoprotein B Degradation Is Promoted by the Molecular Chaperones hsp90 and hsp70Published by Elsevier ,2001
- Posttranslational Quality Control: Folding, Refolding, and Degrading ProteinsScience, 1999
- A Kinetic Mechanism for the Polymerization of α1-AntitrypsinPublished by Elsevier ,1999
- Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.The Journal of cell biology, 1996
- Bidirectional movement of a nascent polypeptide across microsomal membranes reveals requirements for vectorial translocation of proteinsCell, 1992
- Regulation of the mevalonate pathwayNature, 1990