Serum lipids and anticonvulsants

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Abstract
The serum lipid levels of 200 epileptics (aged 20 to 40 years) undergoing long‐term treatment with anticonvulsants were measured and compared with the levels of a normal population of the same age. The epileptics had higher serum lipid levels (especially of apolipoprotein B and HDL‐cholesterol) but no higher incidence of hyperlipemias. A correlation between LDL‐cholesterol and vitamin E has been found in epileptics, but it was not as significant as in normals. In male epileptics, positive correlations between the average daily dose of anticonvulsants (especially of those with a well‐known enzyme‐inducing effect) and triglycerides, cholesterol and LDL‐cholesterol were found; in females there were no significant correlations.