Interferon and Hepatitis B Virus

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Abstract
IN this issue of the Journal Greenberg and his colleagues report that interferon depresses Dane-particle-associated DNA, DNA polymerase and core antigen in chronic active hepatitis. Dane particles are the presumed etiologic virus of Type B hepatitis. It is a pleasant surprise to learn that interferon may have an effect on an established chronic infection caused by a poorly understood but extremely important DNA virus.Interferon, a unique antiviral substance, is a cellular protein that inhibits intracellular viral replication at the level of transcription of the viral genome or the translation of viral proteins. To take effect, cells must usually be . . .

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