Tumor Cell Respiration Following Irradiation

Publisher Website
Google Scholar
Abstract
O2 consumption rates for mouse P815-X2 mastocytoma cells examined 3-24 h after X-irradiation with 250-2000 rads were consistently higher than controls. Cyclic fluctuations in O2 consumption per cell were dose-dependent; peaks in consumption were greater in magnitude and occurred later in time with increasing dose. The cyclic response in consumption is probably due to cell synchronization effects, while the overall higher respiration rates of irradiated cells may reflect increased metabolic activity in response to radiation damage. O2 consumption rates for the total cell population were cyclic after 250 and 500 rads, but declined steadily after 1000 or 2000 rads. O2 consumption rates tended to be lower than controls, especially 12-24 h postirradiation. Differences between cellular and population O2 consumption rates reflect changes in cell number after irradiation. Postirradiation reoxygenation kinetics in solid tumors may result from changes in tumor O2 demand.