Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
Open Access
- 18 November 2005
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 78 (1) , 1-8
- https://doi.org/10.1002/jmv.20499
Abstract
Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. J. Med. Virol. 78:1–8, 2006.Keywords
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