Treatment of recurrent aphthous ulcers with Aureomycin® mouth rinse or Zendium® dentifrice

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Abstract
Clinical trials with a cross-over double-blind technique were undertaken to test chlor-tetracycline (Aureomycin®) and the enzyme-containing dentifrice Zendium® with regard to therapeutic effects on recurrent aphthous ulcers. Aureomycin was found to reduce the number of ulcers and diminish pain when compared with placebo. When groups of patients treated with Zendium and placebo dentifrice, respectively, were compared, no statistically significant difference could be demonstrated. However, when the pH value of Zendium was stepwise changed from 5.9 to 6.8, an increased fraction of patients reported complete relief from pain and ulcer(s) during the trial periods.