Abstract
In the N.M.R.I. mouse which has been treated by prednisolone the blood glucose level is only slightly increased and its turnover rate is not changed; the conversion of glucose to liver glycogen is greatly stimulated and the activity of glycogen synthetase in the liver is increased in a similar proportion, at least when it is measured in a concentrated liver homogenate. This activation of the glycogen synthetase also accounts for a simultaneous decrease in the concentration of UDPG and of glucose 6‐phosphate in the liver.