Prolactin production by immune cells
- 1 October 2001
- journal article
- review article
- Published by SAGE Publications in Lupus
- Vol. 10 (10) , 665-675
- https://doi.org/10.1191/096120301717164895
Abstract
Prolactin (PRL) is a pituitary hormone and a cytokine that plays an important role in rodent and human immune responses, including autoimmune diseases. However, many cells and tissues other than the pituitary make PRL, including immune cells. Here, we will present the evidence demonstrating PRL synthesis by different subtypes of immune cells from humans, mice and rats, describe the regulation of PRL gene expression in human lymphocytes, and discuss the functions of PRL made by immune cells. Finally, we will present evidence for involvement of immune cell PRL in human autoimmune disease and suggest how it might play a unique immunoregulatory role.Keywords
This publication has 55 references indexed in Scilit:
- Humoral and Cell-Mediated Immunity in Mice with Genetic Deficiencies of Prolactin, Growth Hormone, Insulin-like Growth Factor-I, and Thyroid HormoneClinical Immunology, 2000
- Effects of Growth Hormone and Prolactin on HematopoiesisLeukemia & Lymphoma, 2000
- Endocrine, paracrine and autocrine actions of prolactin on immune cellsLife Sciences, 1996
- Evaluation of prolactin-like activity produced by concanavalin-A stimulated mouse splenocytesLife Sciences, 1995
- Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cellsJournal of Cellular Physiology, 1995
- Expression of short and long forms of prolactin receptor in murine lymphoid tissuesMolecular and Cellular Endocrinology, 1994
- Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions.The Journal of Experimental Medicine, 1994
- Concanavalin A-stimulated murine splenocytes produce a factor with prolactin-like bioactivity and immunoreactivityBiochemical and Biophysical Research Communications, 1987
- Detection and enzymatic deglycosylation of a glycosylated variant of prolactin in human plasmaFEBS Letters, 1987
- Prolactin receptors on human lymphocytes and their modulation by cyclosporineBiochemical and Biophysical Research Communications, 1984