Evidence for serotypic variation among bovine rotaviruses

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Abstract
Eight field strains of calf rotavirus from the U.K. were compared by neutralisation tests, using convalescent and hyperimmune antisera. Seven of these strains cross-reacted and were considered to be of one serotype, while the 8th was distinguished by a greater than 20-fold two-way difference in neutralisation titre suggesting a second serotype. Three widely-distributed reference strains (U.K., Northern Ireland and Lincoln) cross-reacted with the strains in the dominant serotype, as did 33 of 42 other field calf rotavirus strains. Nine field strains failed to cross-react with either serotype, suggesting the existence of other potential serotypes in the calf population.