Hepatic Necrosis Associated with Viral Infection after Enflurane Anesthesia

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Abstract
Whenx death from massive hepatic necrosis follows anesthesia, the anesthetic is usually indicted although other potential culprits may be cited. Alternative causes include hepatotoxic drugs1 (e.g., phenelzine, antibiotics or tranquilizers), shock,1 , 2 transfusion,2 hyperpyrexia,2 , 3 sepsis,2 , 3 and viral infection.1 2 3 4 A conclusive diagnosis is rarely made. Some authorities argue for the existence of an identifiable hepatic lesion related to anesthetic exposure,4 and others assert that the association of anesthesia and hepatotoxicity is equivocal.5 In the case of death from massive hepatic necrosis after enflurane anesthesia reported below, a herpes-type virus unquestionably was associated with injury and death.Case ReportA 17-year-old boy in . . .

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