TOXICITY OF GENTAMICIN IN RED-TAILED HAWKS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (7) , 1289-1293
Abstract
Gentamicin sulfate [an antibiotic] at dosage levels of 10 and 20 mg/kg of body wt was administered twice daily i.v. to red-tailed hawks. Clinical signs, water consumption and changes in blood chemical values were monitored. Tissues were examined grossly and ultrastructurally, using light and electron microscopy. Clinical signs of weakness and apnea were attributed to gentamicin-induced neuromuscular blockade in the 20-mg/kg group. Serum values of aspartate transaminase, alanine transaminase, cholesterol, inorganic phosphorus, total protein, albumin and uric acid increased in some birds. There was a decrease in periodic acid-Schiff staining of proximal tubular brush borders. Increased numbers of cytoplasmic lysosomes, many of which contained myelin figures, in renal epithelial cells were seen at the ultrastructural level. All birds given 20 mg/kg died. Both dosage levels were considered toxic in red-tailed hawks.