Peripheral Vascular Responses to Remote Thermal Burns and Frostbite as Influenced by Heparin and Paritol

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Abstract
Evidence presented indicates that a toxic substance released at the site of thermal burns and frostbite activates the vasomotor center and causes remote vasoconstrictions. No reflex dilations following arteriolar constrictions were observed in thermal burn or frostbite cases. However, dilation of venules occurred as a result of partial occlusion of the vessels. Thrombocytosis and white thrombosis occurred in cheek pouch venules after remote and local thermal burn and frostbite injuries. Heparin increased the rate of flow, caused vasodilations and cleared up stasis, but favored thrombocytosis and white thrombosis in the venules. Paritol produced results similar to heparin, but was a more powerful anticoagulant, causing fatal hemorrhages in equivalent dosages.

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