The Growth of T2 Virus on Ultraviolet-killed Host Cells

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Abstract
Cells of Escherichia coli, strain B, were exposed to u.-v. light for various lengths of time, and the interactions of the T2 virus with these irradiated host cells were studied. Cells which had received many lethal doses of irradiation were still capable of absorbing virus particles, and the absorbed virus was able to multiply in the usual way. Continued irradiation reduced the chance of survival of absorbed virus, and the host cells eventually lost their ability to absorb and inactivate virus. The author believes that the constituents of the cell concerned with its continued multiplication differ from those required for virus multiplication, and are more sensitive to irradiation. Elements of the host cells which have been altered by irradiation appear to inactivate virus in much the same way as certain molecules are able to inactivate enzyme molecules of similar structure.
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