PARTIAL AGONIST BEHAVIOUR OF ADENOSINE 5′O‐(2‐THIODIPHOSPHATE) ON HUMAN PLATELETS

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Abstract
1 The effects of an adenosine diphosphate (ADP) analogue, adenosine 5′-O-(2-thiodiphosphate) (ADP-β-S), in which a terminal phosphate oxygen has been replaced by sulphur, were studied on human platelets. 2 ADP-/3-S induced platelet aggregation and inhibited prostaglandin E 1 (PGE 1)-stimulated adenylate cyclase but in both cases was less potent than ADP and did not achieve the same maximal effects. 3 Both actions of ADP could be inhibited by the simultaneous addition of ADP-β-S (50 μm). 4 Aggregation induced by 11α, 9α-epoxymethano prostaglandin H2 (a stable endoperoxide analogue) was not inhibited by simultaneous addition of ADP-β-S (50 μm). 5 The behaviour of ADP-β-S towards human platelets was consistent with it being a partial agonist.