LEAD IONS AND SYNAPTIC TRANSMISSION IN THE SUPERIOR CERVICAL GANGLION OF THE CAT
Open Access
- 1 June 1957
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 12 (2) , 219-222
- https://doi.org/10.1111/j.1476-5381.1957.tb00123.x
Abstract
The perfused superior cervical ganglion of the cat has been used to study the effect of lead ions on synaptic transmission and on the relase of acetylcholine from preganglionic nerve endings. Lead ions, in concentrations of 5 to 40 μM./l., caused block of ganglionic transmission, and reduced the output of acetylcholine. Calcium ions (10 mM./l.) relieved the block produced by lead ions and restored the acetylcholine output. The presence of lead ions does not seem to change the sensitivity of ganglion cells to injected acetylcholine.Keywords
This publication has 9 references indexed in Scilit:
- Sulfhydryl groups of choline acetylaseBiochimica et Biophysica Acta, 1954
- Biophysics of Junctional TransmissionPhysiological Reviews, 1954
- Effect of magnesium and calcium ions on the release of acetylcholineThe Journal of Physiology, 1954
- Acetylcholine release in the cat's superior cervical ganglionThe Journal of Physiology, 1953
- The interaction of plasma proteins with heavy metals and with alkaline earths, with specific anions and specific steroids, with specific polysaccharides and with the formed elements of the bloodDiscussions of the Faraday Society, 1953
- Reversible Poisoning of Nerve Fibres by Heavy-Metal IonsNature, 1951
- The uptake of lead by blood cells as measured with a radioactive isotopeJournal of Cellular and Comparative Physiology, 1944
- THE ACTION OF LEAD ON PHOSPHOCREATINE IN THE MUSCULAR PARALYSIS OF LEAD POISONINGAmerican Journal of Physiology-Legacy Content, 1939