The effect of etretinate compared with different regimens of PUVA in the treatment of persistent palmoplantar pustulosis

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Abstract
Patients with persistent palmoplantar pustulosis (PPP) of long duration were treated with either etretinate or 1 of 3 PUVA [psoralen plus UV-A] regimens. PUVA was given either with oral methoxsalen (13 cases), with a 1% methoxsalen cream (33 cases) or with trioxsalen baths (18 cases). Twenty patients were treated with etretinate. Patients were assessed every 4th week. A mean score for each group was calculated at each visit based on erythema, desquamation, induration and pustulation. The number of pustules was calculated at each visit. After 12 wk, 4 of 28 patients treated with local methoxsalen and 14 of 17 patients with etritinate had completely cleared. At this stage no patient treated with local trioxsalen or oral methoxsalen showed complete clearance.