The sensitizing capacity of atranorin

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Abstract
The allergenic potential of the aromatic lichen substance atranorin was investigated by means of the guinea pig maximization test of Magnusson and Kligman. Sensitivity was induced in 30% of the animals, which corresponds to a moderate allergenic capacity (grade III). This is in agreement with the clinically-observed frequency of 1.5% among patients. A modified photoallergy test on the same animals was performed, but irradiation did not increase the number of positive reactions. Four patients with proven contact sensitivity to atranorin, evernic, usinic or physodic acid, were examined with different dilutions from 0.001-0.1%. Irradiation of the test series did not provoke any clear-cut photoallergic reaction.