Synthesis and pharmacological evaluation of piperidine derivatives with various heterocyclic rings at the 4-position.
- 1 January 1985
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 33 (3) , 1104-1115
- https://doi.org/10.1248/cpb.33.1104
Abstract
A series of piperidine derivatives with various heterocyclic rings at the 4-position was prepared and tested for antihypertensive activity and other biological activities. The antihypertensive effects of the present compounds in the spontaneous hypertensive rat were less potent than those of previously reported compounds. However, among the compounds tested for antiulcer activity and antiinflammatory activity, some exhibited interesting properties.Keywords
This publication has 1 reference indexed in Scilit:
- New antihypertensive agents. I. Synthesis and antihypertensive activity of some 4-piperidylbenzimidazolinone derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982