EFFECT OF PREDNISOLONE ON GLYCOSAMINOGLYCAN COMPONENTS OF REGENERATING ARTICULAR-CARTILAGE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 27  (2-3) , 129-134
Abstract
Investigations were performed on the effect of prednisolone (0.5 mg/kg) on the regenerating femoral articular cartilage of the knee joint in dogs that were subjected to semiarthroplasty. After 70 days of prednisolone treatment the dogs were killed and the regenerating articular cartilage was removed, minced and dried with acetone. The acetone-dried mateial was used for the determination of galactosamine, glucosamine, uronic acid, sulfate, sialic acid and hydroxyproline. Prednisolone treatment elicited a quantitative increase in galactosamine (30.2%), uronic acid (76.2%) and sulfate (9.1%), while no difference was observed in sialic acid content between the treated and untreated groups. The molar ratio of the measured components suggested that prednisolone produced an increase in chondroitin sulfate and hyaluronic acid and a decrease in the keratosulfate content of cartilage. A comparison of the values measured in the regenerating articular cartilage of control and prednisolone-treated dogs the values obtained in the mature articular cartilage showed that prednisolone at least with regards the glycosaminoglycans of the ground substance, had an accelerating effect on cartilage regeneration.

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